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The α-ketoglutarate binds p53 to the destiny of the cell throughout tumor suppression

1.

Waddell, N. et al. Complete genomes are redefining the mutational panorama of pancreatic most cancers. Nature 518, 495-501 (2015).

2

Kastenhuber, E. R. & Lowe, S. W. Contextualization of p53. Cell 170, 1062-1078 (2017).

three

Kruiswijk, F., Labuschagne, C. F. and Vousden, Okay.H. p53 in survival, demise and metabolic well being: a rescuer licensed to kill. Nat. Rev. Mol. Cell Biol. 16, 393-405 (2015).

four

Morris, J.P. IV, Wang, S.C. and Hebrok, M. KRAS, Hedgehog, Wnt and the twisted biology of pancreatic ductal adenocarcinoma improvement. Nat. Rev. Most cancers 10, 683-695 (2010).

5

Bailey, P. et al. Genomic analyzes establish the molecular subtypes of pancreatic most cancers. Nature 531, 47-52 (2016).

6

Ying, H. et al. Oncogenic Kras maintains pancreatic tumors by regulating anabolic glucose metabolism. Cell 149, 656-670 (2012).

seven.

Son, J. et al. Glutamine helps the expansion of pancreatic most cancers by way of a KRAS-regulated metabolic pathway. Nature 496, 101-105 (2013).

eight

Hingorani, S.R. et al. Trp53
R172H and Kras
G12D cooperate to advertise chromosomal instability and largely metastatic pancreatic ductal adenocarcinoma in mice. Most cancers Cell 7, 469-483 (2005).

9

Rhim, A. D. et al. TEM and dissemination precede the formation of pancreatic tumors. Cell 148, 349-361 (2012).

ten.

Saborowski, M. et al. A modular and versatile mannequin of pancreatic most cancers based mostly on ESC. Genes Dev. 28, 85-97 (2014).

11

Feldser, D.M. et al. Particular sensitivity to p53 restoration throughout development of lung most cancers. Nature 468, 572-575 (2010).

12

Junttila, M. R. et al. Selective activation of p53-mediated tumor suppression in high-grade tumors. Nature 468, 567-571 (2010).

13

Martins, C. P., Brown-Swigart, L. & Evan, G. I. Modeling the therapeutic efficacy of p53 restoration in tumors. Cell 127, 1323-1334 (2006).

14

Xue, W. et al. Senescence and tumor clearance are triggered by p53 restoration in murine hepatic carcinomas. Nature 445, 656-660 (2007).

15

Carey, B.W., Finley, L.W., Cross, J.R., Allis, C.D. and Thompson, BC Nature 518, 413-416 (2015).

16

Raffel, S. et al. BCAT1 limits αKG ranges in AML stem cells resulting in hypermethylation of IDHmut-type DNA. Nature 551, 384-388 (2017).

17

Liu, P. S. et al. The a-ketoglutarate orchestrates the activation of macrophages by metabolic and epigenetic reprogramming. Nat. Immunol. 18, 985-994 (2017).

18

Brady, C.A. et al. Separate transcription packages of p53 dictate responses to DNA injury and tumor suppression. Cell 145, 571-583 (2011).

19

Cheng, T. et al. Pyruvate carboxylase is required for progress of tumor cells unbiased of glutamine. Proc. Natl Acad. Sci. USA 108, 8674-8679 (2011).

20

Buenrostro, JD, Giresi, P., Zaba, L., Chang, H., Y. and Greenleaf, WJ Transposition of native chromatin for the institution of quick and delicate epigenomic profiles of open chromatin, binding to DNA and nucleosome place. Nat. Strategies 10, 1213-1218 (2013).

21

Davie, Okay. et al. Discovery of transcription components and regulatory areas liable for tumor improvement in vivo by open chromatin profiling by ATAC-seq and FAIRE-seq PLoS Genet. 11, e1004994 (2015).

22

Hosoda, W. et al. Genetic analyzes of remoted high-grade pancreatic intraepithelial neoplasia (HG-PanIN) reveal an absence of TP53 and SMAD4 alteration. J. Pathol. 242, 16-23 (2017).

23

Wellen, Okay.E. et al. ATP-citrate lyase binds mobile metabolism to histone acetylation. Science 324, 1076-1080 (2009).

24

Cimmino, L. & Aifantis, I. Different roles for mCs and oxidized TFWs. Curr. Opin. Broom. Dev. 42, 1-7 (2017).

25

Yang, H. et al. The event of tumors is related to a lower in TET gene expression and hydroxylation of 5-methylcytosine. Oncogene 32, 663-669 (2013).

26

Xiao, M. et al. Inhibition of α-KG-dependent histone and DNA demethylase by fumarate and succinate that accumulate in mutations of FH and SDH tumor suppressors. Genes Dev. 26, 1326-1338 (2012).

27

Kaelin, W.G., Jr. & McKnight, S.L. Affect of Metabolism on Epigenetics and Illness. Cell 153, 56-69 (2013).

28

Schvartzman, J.M., Thompson, C.B. and Finley, L.W.Sm. Metabolic regulation of chromatin modifications and gene expression. J. Cell Biol. 217, 2247-2259 (2018).

29

Ongusaha, P. P. et al. BRAC1 shifts the p53-mediated cell outcomes to irreversible progress arrest. Oncogene 22, 3749-3758 (2003).

30

Perez, C.A., Ott, J., Mays, J. & Pietenpol. J. A. DNA binding web site consensus p63: identification, evaluation and utility to a p63MH algorithm. Oncogene 26, 7363-7370 (2007).

31.

Fridman, A. L. and Tainsky, M. A. Important pathways of mobile senescence and immortalization revealed by the profile of gene expression. Oncogene 27, 5975-5987 (2008).

32

Kannan, Okay. et al. Identification by microarrays of main and secondary goal genes regulated by p53. Oncogene 20, 2225-2234 (2001).

33

Martínez-Cruz, A.B. et al. Spontaneous squamous cell carcinoma induced by somatic inactivation of retinoblastoma and tumor suppressors Trp53. Most cancers Res. 68, 683-692 (2008).

34

Tang, X., Milyavsky, M., Goldfinger, N. & Rotter, V. The β-amyloid precursor protein APLP1 is a novel goal gene for p53 transcription that will increase neuroblastoma cell demise following genotoxic stress. Oncogene 26, 7302-7312 (2007).

35

Boj, S.F. et al. Organoid fashions of human and mouse pancreatic duct most cancers in mice. Cell 160, 324-338 (2015).

36

Hingorani, S.R. et al. Preinvasive and invasive ductal pancreatic most cancers and its early detection in mice. Most cancers Cell four, 437-450 (2003).

37

Kawaguchi, Y. et al. The function of the transcriptional regulator Ptf1a within the conversion of intestinal progenitors into pancreatic progenitors. Nat. Broom. 32, 128 to 134 (2002).

38

Pan, F.C. et al. Spatiotemporal patterns of multipotentiality in cells expressing Ptf1a throughout organogenesis of the pancreas and facultative restoration induced by damage. Growth 140, 751-764 (2013).

39

Jackson, E.L. et al. Evaluation of the initiation and development of lung tumors utilizing the conditional expression of Okay-ras oncogene. Genes Dev. 15, 3243-3248 (2001).

40

Olive, Okay.P. et al. Mutant p53 acquire operate in two mouse fashions of Li – Fraumeni syndrome. Cell 119, 847-860 (2004).

41

Marino, S., Vooijs, M., van Der Gulden, H., Jonkers, J. and Berns, A. Induction of medulloblastomas in p53-nule mutant mice by somatic inactivation of Rb in cells of the outer granular layer of cerebellum. Genes Dev. 14, 994-1004 (2000).

42

Beard, C., Okay. Hochedlinger, Okay. Plath, A. Wutz and A. Jaenisch. An environment friendly technique for producing single copy transgenic mice by site-specific integration in embryonic stem cells. Genesis 44, 23-28 (2006).

43

Dow, L.E. et al. Conditional inverse tet-transactivator mice strains for environment friendly induction of TRE-regulated transgenes in mice. PLoS ONE 9, 95236 (2014).

44

Weissmueller, S. et al. The p53 mutant causes metastasis of pancreatic most cancers by way of the autonomic PDGF receptor b signaling of cells. Cell 157, 382-394 (2014).

45

Dickins, R.A. et al. Investigation of tumor phenotypes utilizing steady and controlled artificial microRNA precursors. Nat. Broom. 37, 1289-1295 (2005).

46

Fellmann, C. et al. A microRNA skeleton optimized for environment friendly single-copy RNAi. Cell Stories 5, 1704-1713 (2013).

47

Chen, C. et al. The IDH2 mutants related to most cancers trigger acute myeloid leukemia delicate to Brd4 inhibition. Genes Dev. 27, 1974-1985 (2013).

48.

Sanjana, N.E., Shalem, O. and Zhang, F. Enhanced Vectors and Genome-wide Libraries for CRISPR Screening. Nat. Strategies 11, 783-784 (2014).

49

Ruscetti, M. et al. NK cell-mediated cytotoxicity contributes to the management of the tumor by a mix of cytostatic medication. Science 362, 1416-1422 (2018).

50

Aksoy, O. et al. The atypical E2F7 member of the E2F household the p53 and RB pathways throughout mobile senescence. Genes Dev. 26, 1546-1557 (2012).

51.

Morris, J.P., IV et al. Dicer regulates differentiation and viability in the course of the initiation of pancreatic most cancers in mice. PLoS ONE 9, 95486 (2014).

52.

Zafra, M. P. et al. Optimized base editors allow environment friendly enhancing in cells, organelles and mice. Nat. Biotechnol. 36, 888-893 (2018).

53

Bolger, A.M., Lohse, M. and Usadel, B. Trimmomatic: a versatile trimmer for Illumina sequence information. Bioinformatics 30, 2114-2120 (2014).

54

Dobin, A. et al. STAR: ultra-fast common aligner of ARN-seq. Bioinformatics 29, 15-21 (2013).

55

Liao, Y., Smyth, G. Okay. and Shi, W. FeatureCounts: An efficient common function program for assigning sequence readings to genomic options. Bioinformatics 30, 923-930 (2014).

56.

Anders, S., Pyl, P.T. and Huber, W. HTSeq: a Python framework for working with excessive throughput sequencing information. Bioinformatics 31, 166-169 (2015).

57

Love, M. I., Huber, W. and Anders, S. Reasonable estimate of fold change and dispersion for seq-RNA information with DESeq2. Genome Biol. 15, 550 (2014).

58.

Subramanian, A. et al. Gene Enrichment Evaluation: A knowledge-based strategy to decoding genome-wide expression profiles. Proc. Natl Acad. Sci. USA 102, 15545-1550 (2005).

59

Millard, P., Letisse, F., Sokol, S. and Portais, J. C. IsoCor: Correction of MS information in isotopic labeling experiments. Bioinformatics 28, 1294-1296 (2012).

60.

Buenrostro, J.D., Wu, B., Chang, H.Y. and Greenleaf, W.J. ATAC-seq: a technique of assaying the chromatin accessibility to the genome scale. Curr. Protoc. Mol. Biol. 109, 21.29.1-21.29.9 (2015).

61.

Kenzelmann Broz, D. et al. International genomic profiling reveals an in depth p53-regulated autophagy program contributing to key p53 responses. Genes Dev. 27, 1016-1031 (2013).

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