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E-cadherin is required for metastasis in a number of fashions of breast most cancers


Bogenrieder, T. & Herlyn, M. Axis of Evil: Molecular Mechanisms of Most cancers Metastasis. Oncogene 22, 6524-6536 (2003).


Berx, G. et al. E-cadherin is a mutated tumor suppressor / invasion gene in human lobular breast cancers. EMBO J. 14, 6107-6115 (1995).


Frixen, U.H. et al. Cell-to-cell adhesion mediated by E-cadherin prevents invasion of human carcinoma cells. J. Cell Biol. 113, 173-185 (1991).


Li, C.I., Anderson, B.O., Daling, J.R. and Moe, R.E. Tendencies within the incidence charges of invasive carcinomas of the breast, lobes and canals. Jam. Med. Assoc. 289, 1421-1424 (2003).


Nguyen-Ngoc, Okay.V. et al. The microenvironment of the MEC regulates collective migration and native dissemination in regular and malignant mammary epithelium. Proc. Natl Acad. Sci. USA 109, E2595 to E2604 (2012).


Cheung, Okay.J., Gabrielson E., Werb, Z. & Ewald, A.J. A collective invasion of breast most cancers requires a conserved basal epithelial program. Cell 155, 1639-1651 (2013).


Christofori, G. & Semb, H. The Function of the E-cadherin Cell Adhesion Molecule as a Tumor Suppressor Gene. Biochem Tendencies. Sci. 24, 73-76 (1999).


Chambers, A.F., Groom, A.C. and MacDonald, I. C. Dissemination and development of most cancers cells in metastatic websites. Nat. Rev. Most cancers 2, 563-572 (2002).


Sosa, M.S. et al. NR2F1 controls the dormancy of tumor cells by way of quiescence applications pushed by SOX9 and RARβ. Nat. Frequent. 6, 6170 (2015).


Wheelock, M.J., Shintani, Y., Maeda, M., Fukumoto, Y. and Johnson, Okay. R. Cadherin. J. Cell Sci. 121, 727-735 (2008).


Davies, S.R., Watkins, G., Douglas-Jones, A., Mansel, R.E. and Jiang, W.G. Bone morphogenetic proteins 1-7 in human breast most cancers, profile of expression and scientific / prognostic relevance. J. Exp. Ther. Oncol. 7, 327-338 (2008).


Demircan, B. et al. Comparative epigenomics of mammary tumors in people and mice. Chromosome genes. Most cancers 48, 83-97 (2009).


Xue, W. et al. Group of candidate tumor suppressor genes related in chromosomal deletions. Proc. Natl Acad. Sci. USA 109, 8212-8217 (2012).


Jovanovic, I.P. et al. The Interleukin-33 / ST2 axis promotes breast most cancers development and metastasis by facilitating the intratumoral accumulation of immunosuppressive and innate lymphoid cells. Int. J. Most cancers 134, 1669-1682 (2014).


Gao, D. et al. Myeloid progenitor cells of the pre-metastatic lung promote metastasis by inducing a mesenchymal to epithelial transition. Most cancers Res. 72, 1384-1394 (2012).


Day, M. L. et al. E-cadherin is concerned within the survival of epithelial cells of the prostate and mammary epithelium as a perform of aggregation by way of the management of the retinoblastoma cell cycle. J. Biol. Chem. 274, 9656-9664 (1999).


Adamson, G.M. and Billings, R.E. Tumor necrosis issue induced oxidative stress in remoted mouse hepatocytes. Camber. Biochem. Biophys. 294, 223-229 (1992).


Liu, R.M. & Desai, L.P.Regulatory regulation of TGF-β and reactive species of oxygen: A perverse cycle for fibrosis. Redox Biol. 6, 565-577 (2015).


Johnson, T.M., Yu, Z.X., Ferrans, V.J., Lowenstein, R.A. and Finkel, T.Reactive oxygen species are mediators downstream of p53-dependent apoptosis. Proc. Natl Acad. Sci. USA 93, 11848-11852 (1996).


LeBleu, V. S. et al. PGC-1α is concerned in mitochondrial biogenesis and oxidative phosphorylation in most cancers cells to advertise metastasis. Nat. Cell Biol. 16, 992-1003 (2014).


Kerksick, C. and Willoughby, D. The antioxidant position of glutathione and N-acetyl-cysteine ​​dietary supplements and exercise-induced oxidative stress. J. Int. Soc. Sports activities Nutr. 2, 38-44 (2005).


Herrera, B. et al. Reactive oxygen species (ROS) mediate mitochondria – dependent apoptosis induced by reworking development issue β in fetal hepatocytes. FASEB J. 15, 741-751 (2001).


Massaged, J. TGFβ in Most cancers. Cell 134, 215-230 (2008).


Kleer, C., G., van Golen, L., Braun, T. and Merajver, S., D. Persistent Expression of E-cadherin in Inflammatory Breast Most cancers. Mod. Pathol. 14, 458-464 (2001).


Rodriguez, F.J., Lewis-Tuffin, L.J. and Anastasiadis, P. Z. Darkish facet of E-cadherin: attainable position in tumor development. Biochim. Biophys. Acta 1826, 23-31 (2012).


Sundfeldt, Okay. et al. Expression of E-cadherin in epithelial carcinoma of the human ovary and within the regular ovary. Int. J. Most cancers 74, 275-280 (1997).


Kim, S.A. et al. The lack of expression of CDH1 (E-cadherin) is related to infiltrating tumor development and metastasis of the lymph nodes. French. J. Most cancers 114, 199-206 (2016).


McCart Reed, A.E. et al. An epithelial to mesenchymal transition program doesn’t typically govern the phenotype of invasive lobular carcinomas. J. Pathol. 238, 489-494 (2016).


Xu, Y. et al. The precise inactivation of Twist1 in breast tumor cells inhibits the plasticity, dissemination and metastasis of the lungs of most cancers cells in mice. Proc. Natl Acad. Sci. USA 114, 11494-11499 (2017).


Beerling, E. et al. The plasticity between epithelial and mesenchymal states dissociates EMT from the flexibility of stem cells to extend metastasis. Cell Rep. 14, 2281 to 2288 (2016).


Lambert, A.W., Pattabiraman, D.R., and Weinberg, R. A. Rising organic rules of metastasis. Cell 168, 670-691 (2017).


Yates, C.C., Shepard, C.R., Stolz, D.B. and Wells, A. Co-culture of human prostate carcinoma cells with hepatocytes leads to elevated expression of E-cadherin. French. J. Most cancers 96, 1246-1252 (2007).


Brabletz, T. Differentiate or non – pathways to metastasis. Nat. Rev. Most cancers 12, 425-436 (2012).


Man, C.T., Cardiff, R.D. and Muller, W. J. Induction of mammary tumors by the expression of a mean oncogene of the polyomavirus: a transgenic murine mannequin for metastatic illness. Mol. Cell. Biol. 12, 954-961 (1992).


Maroulakou, I. G., M. Anver, Garrett, L. and Inexperienced, J. E. Prostate and mammary adenocarcinoma in transgenic mice bearing a C3 (1) simian virus 40 tumor antigen fusion gene. Proc. Natl Acad. Sci. USA 91, 11236-11240 (1994).


Muzumdar, M., D., Tasic, B., Okay., Miyamichi, L., L. and Luo, L. A Cre double fluorescence reporter mouse. Genesis 45, 593-605 (2007).


Boussadia, O., Kutsch, S., Hierholzer, A., Delmas, V. and Kemler, R. E-cadherin is a survival issue for the mammary gland of lactating mice. Mech. Dev. 115, 53-62 (2002).


Badea, T.C., Wang, Y. and Nathans, J. Noninvasive genetic / pharmacological technique for visualization of mobile morphology and clonal relationships in mice. J. Neurosci. 23, 2314-2322 (2003).


Nguyen-Ngoc, Okay.V. et al. 3D tradition checks of murine mammary department morphogenesis and epithelial invasion. Mol. Biol. 1189, 135-162 (2015).


Langmead, B., Trapnell C., Pop, M. and Salzberg, S. L. Excessive-speed and environment friendly alignment in reminiscence of brief DNA sequences to the human genome. Genome Biol. 10, R25 (2009).


Kim, D. et al. TopHat2: Correct alignment of transcriptomes within the presence of insertions, deletions and gene fusions. Genome Biol. 14, R36 (2013).


Anders, S., Pyl, P.T. and Huber, W. HTSeq: a Python framework for working with excessive throughput sequencing knowledge. Bioinformatics 31, 166-169 (2015).


Love, M. I., Huber, W. and Anders, S. Reasonable estimate of fold change and dispersion for seq-RNA knowledge with DESeq2. Genome Biol. 15, 550 (2014).


Cheung, Okay.J. et al. The polyclonal metastases of breast most cancers end result from the collective dissemination of clusters of tumor cells expressing keratin 14. Proc. Natl Acad. Sci. USA 113, E854 to E863 (2016).


Liberzon, A. et al. Molecular Signatures Database (MSigDB) Bioinformatics 27, 1739-1740 (2011).

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