Opposition of T-cell responses in experimental autoimmune encephalomyelitis
Worldwide Consortium for Genetics of A number of Sclerosis and Wellcome Belief Case 2. Genetic danger and a key position for cell-mediated immune mechanisms in a number of sclerosis. Nature 476, 214-219 (2011).
Fallang, L.-E. et al. The variations in danger of celiac illness related to HLA-DQ2.5 or HLA-DQ2.2 are associated to extended presentation of the gluten antigen. Nat. Immunol. 10, 1096-1101 (2009).
Sollid, L.M., Qiao, S.W., Anderson, R.P., Gianfrani, C. & Koning, F. Nomenclature and record of gluten T cell epitopes related for celiac illness, restricted by HLA-DQ molecules. Immunogenetics 64, 455-460 (2012).
Zamvil, S. et al. T cell clones particular for the myelin core protein induce recurrent persistent paralysis and demyelination. Nature 317, 355-358 (1985).
Blankenhorn, E.P. et al. The genetics of experimental allergic encephalomyelitis helps the position of helper T cells within the pathogenesis of a number of sclerosis. Ann. Neurol. 70, 887-896 (2011).
Skulina, C. et al. A number of Sclerosis: CD8 + T cells infiltrating the mind persist as clonal growth into cerebrospinal fluid and blood. Proc. Natl Acad. Sci. USA 101, 2428-2433 (2004).
Babbe, H. et al. Clonal expansions of CD8 + T cells dominate T cell infiltrate in lively a number of sclerosis lesions, as indicated by micromanipulation and unicellular polymerase chain response. J. Exp. Med. 192, 393-404 (2000).
Blink, S. E. and Miller, S. D. The contribution of γδ T cells to the pathogenesis of EAE and MS. Curr. Mol. Med. 9, 15-22 (2009).
Han, A. et al. Dietary gluten triggers the concomitant activation of αβ T cells and CD4 + γδ T lymphocytes and CD8 + in celiac illness. Proc. Natl Acad. Sci. USA 110, 13073-13078 (2013).
Birnbaum, M.E. et al. Deconstruct peptide-MHC specificity of T cell recognition Cell 157, 1073-1087 (2014).
Gee, M.H. et al. Identification of the orphan T-cell receptor antigen expressed on tumor-infiltrating lymphocytes. Cell 172, 549-563.e16 (2018).
Han, A., Glanville, J., Hansmann, L. and Davis, M. M. Relating the T cell receptor sequence to the practical phenotype on the single cell stage. Nat. Biotechnol. 32, 684-692 (2014).
Wei, Y.-L. et al. A repertoire of extremely concentrated antigen receptors characterizes γδ T lymphocytes which can be about to provide IL-17 quickly in naive animals. Entrance. Immunol. 6, 118 (2015).
Langrish, C.L. et al. IL-23 leads to a pathogenic T cell inhabitants that induces autoimmune irritation. J. Exp. Med. 201, 233-240 (2005).
Kroenke, MA, Carlson, TJ, Andjelkovic, AV and Segal, BM IL-12 and IL-23 modulated T cells induce distinct sorts of EAE on the idea of histology, chemokine profile CNS and response to cytokine inhibition. J. Exp. Med. 205, 1535-1541 (2008).
Ben-Nun, A., Wekerle, H. and Cohen, I. R. Speedy isolation of clonable T-cell traces particular for antigen able to mediating autoimmune encephalomyelitis. EUR. J. Immunol. 11, 195-199 (1981).
Jäger, A., Dardalhon, V., Sobel, R.A., Bettelli, E. & Kuchroo, V.Ok. Th1, Th17 and Th9 effector cells induce experimental autoimmune encephalomyelitis with varied pathological phenotypes. J. Immunol. 183, 7169-7177 (2009).
Denton, A.E. et al. Affinity thresholds for naïve activation of CD8 + CTL by peptides and influenza A viruses dealt with. J. Immunol. 187, 5733-5744 (2011).
Day, E.B. et al. Structural foundation for T cell receptor variety in biased responses of virus-specific CD8 + T cells. Proc. Natl Acad. Sci. USA 108, 9536-9541 (2011).
Moon, J. J. et al. The frequency of naive CD4 + T cells varies for various epitopes and predicts the variety of the repertoire and the magnitude of the response. Immunity 27, 203-213 (2007).
Kim, H.-J. & Cantor, H. Regulation of self-tolerance by Q8-restricted CD8 + regulatory T cells. Semin. Immunol. 23, 446-452 (2011).
Lu, L., Kim, H.-J., Werneck, M.B.F. and Cantor, H. Regulation of CD8 + regulatory T cells: Interrupting NKG2A-Qa-1 interplay permits sturdy suppressive exercise and backbone of autoimmune illnesses. Proc. Natl Acad. Sci. USA 105, 19420-19425 (2008).
Kim, H.-J. et al. CD8 + T regulatory cells categorical the Ly49 MHC class I receptor 49 and are faulty in B6-Yaa mice with autoimmune tendency. Proc. Natl Acad. Sci. United States of America 108, 2010-2015 (2011).
Agarwal, R. Ok. & Caspi, R. R. Rodent fashions of experimental autoimmune uveitis. Mol. Med. 102, 395-419 (2004).
Zemmour, D. et al. The expression of single-cell genes reveals a panorama of regulatory phenotypes of T cells shaped by the TCR. Nat. Immunol. 19, 291-301 (2018).
Hvas, J., Oksenberg, J., Fernando, R., Steinman, L. and Bernard, C. C. Listing of γδ T cell receptors in mind lesions of sufferers with a number of sclerosis. J. Neuroimmunol. 46, 225-234 (1993).
Wucherpfennig, Ok.W. et al. Listing of gamma delta T cell receptors in acute lesions of a number of sclerosis. Proc. Natl Acad. Sci. USA 89, 4588-4592 (1992).
Gandhi, R., Laroni, A. and Weiner, H. L. Function of the innate immune system within the pathogenesis of a number of sclerosis. J. Neuroimmunol. 221, 7-14 (2010).
Caccamo, N. et al. Differentiation, phenotype and performance of interleukin-17 producing Vγ9Vδ2 human T cells. Blood 118, 129-138 (2011).
Moens, E. et al. IL-23R and TCR signaling drives the technology of Vγ9Vδ2 neonatal T cells expressing excessive ranges of cytotoxic mediators and producing IFN-γ and IL-17. J. Leukoc. Biol. 89, 743-752 (2011).
Sutton, C.E. et al. Interleukin-1 and IL-23 induce innate manufacturing of IL-17 from γδ T cells, enhancing Th17 responses and autoimmunity. Immunity 31, 331-341 (2009).
Value, A.E., Reinhardt, R.L., Liang, H.-E. & Locksley, R. M. Labeling and quantification of IL-17A producing cells in vivo. PLoS ONE 7, e39750 (2012).
Harrington, L.E. et al. CD4 + effector T cells producing interleukin 17 develop by way of a definite lineage of T helper traces of sorts 1 and a couple of. Nat. Immunol. 6, 1123-1132 (2005).
Elias, D., Tikochinski, Y., Frankel, G. and Cohen, I. R. Regulation of Autoimmune Diabetes of NOD Mice by T Cells That Acknowledge a TCR CDR3 Peptide. Int. Immunol. 11, 957-966 (1999).
Kumar, V., Stellrecht, Ok. & Sercarz, E. Inactivation of CD4-regulatory T lymphocytes particular for T-cell receptor peptide induces persistent experimental autoimmune encephalomyelitis (EAE). J. Exp. Med. 184, 1609-1617 (1996).
Hu, D. et al. Evaluation of CD8 regulatory T cells in Qa-1 poor mice. Nat. Immunol. 5, 516-523 (2004).
Panoutsakopoulou, V. et al. Suppression of an autoimmune illness after vaccination with autoreactive T cells that categorical peptide complexes Qa-1. J. Clin. Make investments. 113, 1218-1224 (2004).
Stadinski, B.D. et al. Diabetogenic T cells acknowledge insulin-related IAg7 in an surprising and weakly binding routine. Proc. Natl Acad. Sci. USA 107, 10978-10983 (2010).
Altman, J. D. et al. Phenotypic evaluation of antigen particular T lymphocytes. Science 274, 94-96 (1996).
Davis, M. M. & Brodin, P. Restarting Human Immunology. Annu. Rev. Immunol. 36, 843-864 (2018).
O'Shea, E. Ok., Lumb, Ok.J. & Kim, P. S. Peptide "Velcro": design of a heterodimeric coiled coil. Curr. Biol. three, 658-667 (1993).
Adams, J. J. et al. T-cell receptor signaling is restricted by the anchoring of the geometry to the peptide-major histocompatibility complicated. Immunity 35, 681-693 (2011).
Nelson, R. W. et al. Cross-reactivity of T cell receptors between comparable overseas and autonomic peptides influences the scale of the naive cell inhabitants and autoimmunity. Immunity 42, 95-107 (2015).
Grotenbreg, G. M. et al. Discovery of CD8 + T cell epitopes in Chlamydia trachomatis an infection by means of class I tetramers of cage MHC. Proc. Natl Acad. Sci. USA 105, 3831-3836 (2008).
Krementsov, D.N. et al. Particular intercourse management of central nervous system autoimmunity by signaling p38 mitogen-activated protein kinase in myeloid cells. Ann. Neurol. 75, 50-66 (2014).
Tennakoon, D.Ok. et al. Therapeutic induction of regulatory and cytotoxic CD8 + T lymphocytes in a number of sclerosis. J. Immunol. 176, 7119-7129 (2006).
Bian, Y. et al. The MHC Ib Qa-1 molecule presents the peptide antigens of Mycobacterium tuberculosis to CD8 + T cells and contributes to the safety towards infections. PLoS Pathog. 13, e1006384 (2017).
Mahajan, V.B., Skeie, J.M., Assefnia, A.H., Mahajan, M. and Tsang, S.H. Enucleation of eyes in mice for distant high-throughput phenotyping. J. Vis. Exp. 57, e3184 (2011).