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Don’t throw Staphylococcus aureus WTA as vaccine antigen


Gerlach, D. et al. Methicillin-resistant Staphylococcus aureus alters glycosylation of the cell wall to flee immunity. Nature 563, 705-709 (2018).


Driguez, P.A. et al. Immunogenic compositions towards S. aureus. The patent WO WO / 2017/064190 (2017).


Xia, G. et al. Glycosylation of teichoic acid within the partitions of Staphylococcus aureus by TarM. J. Biol. Chem. 285, 13405-13415 (2010).


Brown, S. et al. Methicillin resistance in Staphylococcus aureus requires teichoic acids with a glycosylated wall. Proc. Natl Acad. Sci. USA 109, 18909-18914 (2012).


Brown, E.J. et al. Teichoic anti-wall and conjugate antibodies. The patent WO WO / 2014/194247 (2015).


Kurokawa, Ok. et al. Staphylococcal wall teichoic acid glycoepitopes regulate complement-mediated opsonophagocytosis by way of human serum antibodies and mannose binding lectin. J. Biol. Chem. 288, 30956-30968 (2013).


Lee, J.H. et al. Floor glycopolymers are important for complement activation induced by anti-wall IgG and opsonophagocytosis of Staphylococcus aureus in vitro. Infect. Immun. 83, 4247-4255 (2015).


Lehar, S. M. et al. A brand new antibody-antibiotic conjugate removes intracellular S. aureus. Nature 527, 323-328 (2015).


Jung, D.J. et al. Particular serum Ig recognizing teichoic staphylococcal acid induces complement-mediated opsonophagocytosis towards Staphylococcus aureus. J. Immunol. 189, 4951-4959 (2012).

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