The meningeal lymphatic vessels on the base of the cranium drain the cerebrospinal fluid
Louveau, A. et al. Structural and purposeful options of the lymphatic vessels of the central nervous system. Nature 523, 337-341 (2015).
Aspelund, A. et al. Dural lymphatic vascular system that drains interstitial fluid from the mind and macromolecules. J. Exp. Med. 212, 991-999 (2015).
Antila, S. et al. Growth and plasticity of the meningeal lymphatic vessels. J. Exp. Med. 214, 3645-3667 (2017).
Da Mesquita, S. et al. Purposeful facets of meningeal lymphatics in ageing and Alzheimer's illness. Nature 560, 185-191 (2018).
Louveau, A. et al. Lymphatic drainage and neuroinflammation of the CNS are regulated by the meningeal lymphatic vasculature. Nat. Neurosci. 21, 1380-1391 (2018).
Patel, T. Ok. et al. The dural lymphatics regulate the clearance of extracellular tau protein from the central nervous system. Mol. Neurodégénére. 14, 11 (2019).
Tarasoff-Conway, J.M. et al. Techniques of clearance within the mind – implications for Alzheimer's illness. Nat. Rev. Neurol. 11, 457-470 (2015).
Da Mesquita, S., Fu, Z. & Kipnis, J. The meningeal lymphatic system: a brand new participant in neurophysiology. Neuron 100, 375-388 (2018).
Ma, Q., Ineichen, B.V., Detmar, M. & Proulx, S.T .. The stream of cerebrospinal fluid is principally by the lymphatic vessels and is lowered in older mice. Nat. Widespread. eight, 1434 (2017).
Lukić, I. Ok., Gluncić V., Ivkić G., Hubenstorf, M. & Marusić A. Digital Dissection: An Eighteenth-Century Lesson. Lancet 362, 2110-2113 (2003).
Forstmann, B. U., G. Hollander, L. van Maanen, A. Alkemade, A. & Keuken, M. C. In the direction of a mechanistic understanding of the human sub-cortex. Nat. Rev. Neurosci. 18: 57-65 (2016).
Petrova, T. V. & Koh, G. Y. Organ Particular Lymphatic Vascular System: From Growth to Pathophysiology. J. Exp. Med. 215, 35-49 (2018).
Aspelund, A., Robciuc, M.R., Karaman, S., Makinen, T. and Alitalo, Ok. Lymphatic System in Cardiovascular Medication. Circ. Res. 118, 515-530 (2016).
Margaris, Ok. N. and Black, R. A. Lymphatic System Modeling: Challenges and Alternatives. J. R. Soc. Interface 9, 601 to 612 (2012).
Brakenhielm, E. & Alitalo, Ok. Cardiac lymphatics in well being and illness. Nat. Rev Cardiol. 16, 56-68 (2019).
Baluk, P. et al. Functionally specialised junctions between the endothelial cells of the lymphatic vessels. J. Exp. Med. 204, 2349-2362 (2007).
Choi, I. et al. Visualization of lymphatic vessels by a GFP reporter pushed by the Prox1 promoter in a chromosome-based synthetic bacterial transgenic mouse. Blood 117, 362-365 (2011).
Absinta, M. et al. The human and nonhuman meninges of meninges harbor lymphatic vessels that may be visualized non-invasively by MRI. eLife 6, 29738 (2017).
Gousopoulos, E., Proulx, S.T., J. Scholl, Uecker, M. and Detmar, M. Hyperplasia of distinguished lymphatic vessels with progressive dysfunction and distinct infiltration of immune cells into lymphoedema. A m. J. Pathol. 186, 2193-2203 (2016).
Sabine, A. et al. Mechanotransduction, PROX1 and FOXC2 cooperate to regulate connexin37 and calcineurin throughout lymphatic valve formation. Dev. Cell 22, 430-445 (2012).
Candy, D. T. et al. Lymphatic stream regulates the maturation of accumulating lymphatic vessels in vivo. J. Clin. Make investments. 125, 2995-3007 (2015).
Sabine, A. et al. FOXC2 and fluid shear stress stabilize the postnatal lymphatic vasculature. J. Clin. Make investments. 125, 3861-3877 (2015).
Cho, H. et al. YAP and TAZ negatively regulate Prox1 throughout developmental and pathological lymphangiogenesis. Circ. Res. 124, 225-242 (2019).
Zolla, V. et al. The anatomical and biochemical modifications related to ageing lymphatic collectors alter the transport of lymph, fluid homeostasis and clearance of pathogens. Getting old Cell 14, 582-594 (2015).
Bazigou, E. et al. Genes regulating lymphangiogenesis management the formation and upkeep of the venous valve in mice. J. Clin. Make investments. 121, 2984-2992 (2011).
Haiko, P. et al. The suppression of vascular endothelial progress issue C (VEGF-C) and VEGF-D just isn’t equal to the suppression of VEGF receptor three in mouse embryos. Mol. Cell. Biol. 28, 4843-4850 (2008).
Yushkevich, P.A. et al. Person-guided 3D energetic segmentation of anatomical constructions: considerably improved effectivity and reliability. Neuroimage 31, 1116-1128 (2006).
Ineichen, B.V. et al. Direct and long-term intrathecal software of therapeutic merchandise to the rodent's CNS. Nat. Protocols 12, 104-131 (2017).