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Decision of the mobile structure of medulloblastoma by single-cell genomics


Gajjar, A.J. & Robinson, G.W. Medulloblastoma – translating bedside findings. Nat. Rev. Clin. Oncol. 11, 714-722 (2014).


Taylor, M.D. et al. Molecular subgroups of medulloblastoma: the present consensus. Acta Neuropathol. 123, 465-472 (2012).


Northcott, P.A. et al. The complete genome panorama of medulloblastoma subtypes. Nature 547, 311-317 (2017).


Lin, C. Y. et al. Lively activators of medulloblastoma reveal subgroup-specific cell origins. Nature 530, 57-62 (2016).


Hovestadt, V. et al. Decoding the regulatory panorama of medulloblastoma utilizing DNA methylation sequencing. Nature 510, 537-541 (2014).


Northcott, P.A. et al. Subunit-specific structural variation in 1000 medulloblastoma genomes. Nature 488, 49-56 (2012).


Northcott, P.A. et al. Medulloblastomics: the top of the start. Nat. Rev. Most cancers 12, 818-834 (2012).


Gibson, P. et al. Medulloblastoma subtypes have distinct developmental origins. Nature 468, 1095-1099 (2010).


Yang, Z.J. et al. Medulloblastoma might be initiated by the suppression of restricted stem cells or progenitors within the lineage. Most cancers Cell 14, 135-145 (2008).


Oliver, T. G. et al. Patch loss and disruption of granular cell improvement on the pre-neoplastic stage of medulloblastoma. Improvement 132, 2425-2439 (2005).


Cho, Y.J. et al. Integrative genomic evaluation of medulloblastoma identifies a molecular subgroup that ends in poor medical outcomes. J. Clin. Oncol. 29, 1424-1430 (2011).


Tanay, A. & Regev, A. Scaling up the unicellular genomics of phenomenology to mechanism. Nature 541, 331-338 (2017).


Tirosh, I. et al. Unicellular RNA-seq helps a improvement hierarchy within the human oligodendroglioma. Nature 539, 309-313 (2016).


Filbin, M. G. et al. Developmental and oncogenic applications in H3K27M gliomas dissected by a single RNA-seq cell. Science 360, 331-335 (2018).


Patel, A.P. et al. Monocellular RNA-seq highlights intratumoral heterogeneity within the major glioblastoma. Science 344, 1396-1401 (2014).


Venteicher, A. S. et al. Decoupling of genetics, lineages and microenvironment in IDH mutant gliomas by sequencing of unicellular RNA. Science 355, eaai8478 (2017).


Hovestadt, V. et al. Strong molecular subgroup and copy-number profiling of medulloblastoma from small quantities of archival tumor materials utilizing high-density DNA methylation templates. Acta Neuropathol. 125, 913-916 (2013).


Picelli, S. et al. Full-length RNA-seq from single cells utilizing Sensible-seq2. Nat. Protocols 9, 171 to 181 (2014).


Northcott, P.A. et al. Quick, dependable and reproducible molecular subset of medical samples of medulloblastomas. Acta Neuropathol. 123, 615-626 (2012).


Carter, S. L. et al. Absolute quantification of alterations of somatic DNA in human most cancers. Nat. Biotechnol. 30, 413-421 (2012).


Carter, R. A. et al. Monocellular transcriptional atlas of creating murine cerebellum. Curr. Biol. 28, 2910-22020 (2018).


Kool, M. et al. Molecular subgroups of medulloblastoma: worldwide meta-analysis of the transcriptome, genetic aberrations and medical information on medulloblastomas WNT, SHH, teams three and four. Acta Neuropathol. 123, 473-484 (2012).


Waszak, S.M. et al. Spectrum and prevalence of genetic predispositions in medulloblastoma: retrospective genetic research and potential validation in a cohort of medical trials. Lancet Oncol. 19, 785-798 (2018).


Shih, D.J. et al. Cytogenetic prognosis in subgroups of medulloblastomas. J. Clin. Oncol. 32, 886-896 (2014).


Northcott, P.A. et al. Sonic medulloblastomas for hedgehogs in kids and adults are clinically and molecularly distinct. Acta Neuropathol. 122, 231-240 (2011).


Kool, M. et al. Sequencing of the medulloblastoma SHH genullome predicts the genotype-related response to smoothed inhibition. Most cancers Cell 25, 393-405 (2014).


Merk, D.J. et al. The alternative results of CREBBP mutations govern the phenotype of Rubinstein-Taybi syndrome and grownup SHH medulloblastoma. Dev. Cell 44, 709-724 (2018).


Northcott, P.A. et al. Medulloblastoma contains 4 distinct molecular variants. J. Clin. Oncol. 29, 1408-1414 (2011).


Jones, D. T. et al. To dissect the genomic complexity underlying medulloblastoma. Nature 488, 100-105 (2012).


Cavalli, F.M.G. et al. Intertumoral heterogeneity inside subgroups of medulloblastomas Most cancers Cell 31, 737-754 (2017).


Schwalbe, E.C. et al. New molecular subgroups for medical classification and consequence prediction in childish medulloblastoma: a cohort research. Lancet Oncol. 18, 958-971 (2017).


Sharma, T. et al. Second-generation molecular subgroup of medulloblastoma: worldwide meta-analysis of the subtypes of teams three and four. Acta Neuropathol. (2019).


Chizhikov, V.V. et al. Lmx1a regulates the destiny and placement of cells from the cerebellar rhombic lip and the telencephalic cortical hem. Proc. Natl Acad. Sci. USA 107, 10725-10730 (2010).


Englund, C. et al. The unipolar brush cells of the cerebellum are produced within the rhombic lip and migrate by the creating white matter. J. Neurosci. 26, 9184-9195 (2006).


Capper, D. et al. Classification based mostly on DNA methylation of central nervous system tumors. Nature 555, 469-474 (2018).


Rusch, M. et al. Genomic profiling of medical most cancers by sequencing into three platforms of the complete genome, complete exome and transcriptome. Nat. Widespread. 9, 3962 (2018).


Li, B. and Dewey, C. N. RSEM: Exact transcript quantification from seq. RNA information with or with out reference genome BMC Bioinformatics 12, 323 (2011).


Gaujoux, R. & Seoighe, C. A versatile R package deal for non-negative matrix factorization. BMC Bioinformatics 11, 367 (2010).


Wolf, F. A., Angerer, P. & Theis, F. J. SCANPY: Massive-scale evaluation of single-cell gene expression information. Genome Biol. 19, 15 (2018).


Butler, A., Hoffman, P., Smibert, P., Papalexi, E. and Satija, R. Integration of unicellular transcriptomic information beneath totally different circumstances, applied sciences and species. Nat. Biotechnol. 36, 411-420 (2018).


Pöschl, J. et al. Genomic and transcriptomic analyzes set up a correspondence between murine fashions of medulloblastomas and their human counterparts. Acta Neuropathol. 128, 123-136 (2014).


Tamayo, P. et al. Metagen projection for multi-platform and multi-species characterization of worldwide transcription states. Proc. Natl Acad. Sci. USA 104, 5959-5964 (2007).

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