Nature News

Neuronal vulnerability and multi-lineage variety in a number of sclerosis

1.

GBD 2015 Collaborators on the incidence and prevalence of ailments and accidents. Incidence, prevalence and years lived with incapacity for 310 ailments and accidents globally, regionally and nationally, 1990-2015: systematic evaluation for the 2015 World Burden of Illness Research. Lancet 388, 1545-1602 (2016) .

2

Reich, D.S., Lucchinetti, C.F. & Calabresi, P.A. A number of sclerosis. N. Engl. J. Med. 378, 169-180 (2018).

three

Lassmann, H. Pathology of a number of sclerosis. Harb Spring Spring. Perspective. Med. eight, a028936 (2018).

four

Trapp, B.D. et al. Axonal transection in a number of sclerosis lesions. N. Engl. J. Med. 338, 278-285 (1998).

5

Schirmer, L., Antel, J.P., Bruck, W. & Stadelmann, C. Adjustments in axonal loss and phosphorylation of neurofilaments accompany the event of the lesion and the medical development of a number of sclerosis. Mind Pathol. 21, 428-440 (2011).

6

Peterson, J. W., Bö, L., Mörk, S., A. Chang and Trapp, B. D. Transected neurites, apoptotic neurons and decreased irritation in cortical lesions of a number of sclerosis. Ann. Neurol. 50, 389-400 (2001).

7.

Magliozzi, R. et al. The meningeal B cell follicles in secondary progressive a number of sclerosis are related to early onset of the illness and extreme cortical pathology. Mind 130, 1089-1104 (2007).

eight

Magliozzi, R. et al. A gradient of neuronal loss and meningeal irritation in a number of sclerosis. Ann. Neurol. 68, 477-493 (2010).

9

Lucchinetti, C.F. et al. Inflammatory cortical demyelination in early a number of sclerosis. N. Engl. J. Med. 365, 2188-2197 (2011).

ten.

Trapp, B.D. et al. Cortical neuronal density and demyelination of cerebral white matter in a number of sclerosis: a retrospective research. Lancet Neurol. 17: 870-884 (2018).

11

Dal-Bianco, A. et al. Sluggish growth of a number of sclerosis lesions on the iron rim: pathology and magnetic resonance imaging 7 T. Acta Neuropathol. 133, 25-42 (2017).

12

Mainero, C. et al. A gradient of cortical pathology in a number of sclerosis by quantitative imaging 7 T in vivo. Mind 138, 932-945 (2015).

13

Jäkel, S. et al. Altered heterogeneity of human oligodendrocytes in a number of sclerosis. Nature 566, 543-547 (2019).

14

Masuda, T. et al. Spatial and temporal heterogeneity of mouse and human microglia at single-cell decision. Nature 566, 388-392 (2019).

15

Lake, B.B. et al. Neuronal subtypes and variety revealed by single-core RNA sequencing of the human mind. Science 352, 1586-1590 (2016).

16

Lodato, S. & Arlotta, P. Era of neuronal variety within the mammalian cerebral cortex. Annu. Rev. Cell Dev. Biol. 31, 699-720 (2015).

17

Lee, S. et al. NORAD non-coding RNA regulates genomic stability by sequestering PUMILIO proteins. Cell 164, 69-80 (2016).

18

Mus, E., Hof, P.R. & Tiedge, H. Dendritic BC200 RNA in Getting older and Alzheimer's Illness. Proc. Natl Acad. Sci. USA 104, 10679-10684 (2007).

19

Bayraktar, O.A. et al. In situ monocellular transcriptomic map of the cortical layer variety of astrocytes. Preprint on https://doi.org/10.1101/432104 (2018).

20

Machado-Santos, J. et al. The compartmentalized inflammatory response in a number of sclerosis mind consists of tissue-resident CD8 + T cells and B cells. Mind 141, 2066-2082 (2018).

21

Pasetto, L. et al. Concentrating on extracellular cyclophilin A reduces neuroinflammation and prolongs survival in a mouse mannequin of amyotrophic lateral sclerosis. J. Neurosci. 37, 1413-1427 (2017).

22

Liddelow, S.A. et al. Reactive neurotoxic astrocytes are induced by activated microglia. Nature 541, 481-487 (2017).

23

Anderson, M.A. et al. The formation of astrocyte scars promotes the regeneration of axons of the central nervous system. Nature 532, 195-200 (2016).

24

Chang, A. et al. Cortical remyelination: a brand new goal for restorative therapies in a number of sclerosis. Ann. Neurol. 72, 918-92 (2012).

25

Ousman, S. S. et al. Protecting and therapeutic position of αB-crystalline in autoimmune demyelination. Nature 448, 474-479 (2007).

26

Schirmer, L. et al. Differential lack of KIR4.1 immunoreactivity in a number of sclerosis lesions. Ann. Neurol. 75, 810-828 (2014).

27

Gadea, A., Schinelli, S. & Gallo, V. Endothelin-1 regulates the proliferation of astrocytes and reactive gliosis through a JNK / c-Jun signaling pathway. J. Neurosci. 28, 2394-2408 (2008).

28

Hametner, S. et al. Iron and neurodegeneration within the mind with a number of sclerosis. Ann. Neurol. 74, 848-861 (2013).

29

Fard, M.Ok. et al. The BCAS1 expression defines a inhabitants of early myelinating oligodendrocytes in a number of sclerosis lesions. Sci. Trad. Med. 9, eaam7816 (2017).

30

Brophy, P.J., Boccaccio, G.L. and Colman, D. R. The distribution of mRNAs of the myelin primary protein in myelinating oligodendrocytes. Neurosci Developments. 16, 515-521 (1993).

31.

Zrzavy, T. et al. Lack of "homeostatic" microglia and fashions of activation of those cells in energetic a number of sclerosis. Mind 140, 1900-1913 (2017).

32

Lucchinetti, C. et al. Heterogeneity of a number of sclerosis lesions: implications for the pathogenesis of demyelination. Ann. Neurol. 47, 707-717 (2000).

33

Haider, L. et al. The topography of demyelination and neurodegeneration within the mind with a number of sclerosis. Mind 139, 807-815 (2016).

34

Hauser, S. L. et al. Exhaustion of B-cells with rituximab in relapsing-remitting a number of sclerosis. N. Engl. J. Med. 358, 676-688 (2018).

35

Munschauer, M. et al. NORAD RNA assembles a posh of topoisomerase important for genome stability. Nature 561, 132-136 (2018).

36

Campbell, G. R. et al. Deletions of mitochondrial DNA and neurodegeneration in a number of sclerosis. Ann. Neurol. 69, 481-492 (2011).

37

Fischer, M.T. et al. Illness-specific molecular occasions in cortical lesions of a number of sclerosis. Mind 136, 1799-1815 (2013).

38

Carassiti, D. et al. Neuronal loss, demyelination and quantity change within the neocortex for a number of sclerosis. Neuropathol. Appl. Neurobiol. 44, 377-390 (2018).

39

Absinta, M. et al. The persistent rim of part 7 teslas predicts a poor prognosis for brand new lesions in sufferers with a number of sclerosis. J. Clin. Make investments. 126, 2597-2609 (2016).

40

Falcão, A.M. et al. The cells of the oligodendrocyte lineage particular to the illness seem in a number of sclerosis. Nat. Med. 24, 1837-1844 (2018).

41

Kirby, L. et al. Oligodendrocyte precursor cells are co-opted by the immune system to cross-present the antigen and guarantee cytotoxicity. Preprint on https://doi.org/10.1101/461434 (2018).

42

Matevossian, A. & Akbarian, S. Isolation of neuronal nuclei from human autopsy mind tissue. J. Vis. Exp. 20, e914 (2008).

43

Shekhar, Ok. et al. Full classification of retinal bipolar neurons by unicellular transcriptomic. Cell 166, 1308-1323 (2016).

44

Maaten, L. d. & Hinton, G. Viewing knowledge utilizing t-SNE. J. Mach. Study. Res. 9, 2579-2605 (2008).

45

Finak, G. et al. MAST: A versatile statistical framework for evaluating transcriptional adjustments and characterizing heterogeneity in single-cell RNA sequencing knowledge. Genome Biol. 16, 278 (2015).

46

Love, M. I., Huber, W. and Anders, S. Reasonable estimate of fold change and dispersion for seq-RNA knowledge with DESeq2. Genome Biol. 15, 550 (2014).

47

Trapnell, C. et al. The dynamics and regulators of selections concerning the destiny of cells are revealed by the pseudotemporal order of single cells. Nat. Biotechnol. 32, 381-386 (2014).

48.

Yu, G., Wang, L.-G., Han, Y. & He, Q.-Y. clusterProfiler: an R package deal that compares organic themes amongst clusters of genes. OMICS 16, 2013-2011.0118 (2014).

49

Aibar, S. et al. SCENIC: Inference and clustering in a single-cell regulatory community. Nat. Strategies 14, 1083-1086 (2017).

50

Meguro, R. et al. Histochemistry of nonhemic iron in optical and digital microscopy: historic, theoretical and technical outcomes. Camber. Histol. Cytol. 70, 1-19 (2007).

51.

Jahn, O., Tenzer, S., Bartsch, N., Patzig, J. and Werner, H. B. in The Cytoskeleton (ed Dermietzel, R.) 335-353 (Humana, 2013).

52

Werneburg, S., M. Mühlenhoff, M. Stangel, M. & Hildebrandt, H. Polysialic acid on SynCAM 1 in NG2 cells and on neuropilin-2 in microglia is confined to intracellular swimming pools that Exhaust rapidly throughout stimulation. Glia 63, 1240-1255 (2015).

53

Schafer, D.P. et al. Microglia sculpts postnatal neuronal circuits in a fashion depending on complement and exercise. Neuron 74, 691-705 (2012).

54

Chen, Y. et al. NS21: B27 complement redefined and modified for neuronal cultures. J. Neurosci. Strategies 171, 239-247 (2008).

Leave a Reply

Your email address will not be published. Required fields are marked *