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Enabling PDGF Channel Hyperlinks LMNA mutation in dilated cardiomyopathy

1.

Carmosino, M. et al. Position of nuclear laminate A / C in cardiomyocyte features. Biol. Cell 106, 346-358 (2014).

2

Fatkin, D. et al. Missense mutations within the subject of laminated A / C gene rods as causes of dilated cardiomyopathy and conduction system illness. N. Engl. J. Med. 341, 1715-1724 (1999).

three

Krohne, G. & Benavente, R. The nuclear lamines. Exp. Cell Res. 162, pp 1-10 (1986).

four

Hershberger, R.E. & Morales, A. in GeneReviews (eds Pagon, R.A. et al.) (College of Washington, 1993).

5

Hershberger, R.E., Hedges, D.J. and Morales, A. Dilated cardiomyopathy: the complexity of a various genetic structure. Nat. Rev Cardiol. 10: 531-547 (2013).

6

Tesson, F. et al. Mutations of the A / C layer in dilated cardiomyopathy. Cardiol. J. 21, 331-342 (2014).

7.

Diecke, S. et al. A novel codon-optimized mini-intron plasmid for environment friendly, cheap and xenophobia-free pluripotency induction. Sci. Rep. 5, 8081 (2015).

eight

Kodo, Okay. et al. Cardiomyocytes derived from iPSC reveal irregular signaling of TGF-β in left ventricular cardiomyopathy with out compaction. Nat. Cell Biol. 18, 1031-1042 (2016).

9

Lee, J. et al. SETD7 promotes the engagement of the cardiac lineage with particular transcriptional activation at every stage. Cell Stem Cell 22, 428-444 (2018).

ten.

Burridge, P.W. et al. Chemically outlined era of human cardiomyocytes. Nat. Strategies 11, 855-860 (2014).

11

Karakikes, I. et al. A whole TALEN-based inactivation library to generate human-induced pluripotent stem cell-derived fashions for heart problems. Circ. Res. 120, 1561-1571 (2017).

12

Termglinchan, V., Seeger, T., Chen, C., Wu, J.C. and Karakikes, I. in Cardiac Gene Remedy (Ishikawa, Okay., eds.) 55-68 (Springer, New York, 2017).

13

Bers, D. M. Biking and calcium signaling in cardiac myocytes. Annu. Rev. Physiol. 70, 23-49 (2008).

14

Lan, F. et al. Irregular calcium therapy properties are on the root of the familial pathology of familial hypertrophic cardiomyopathy in patient-induced pluripotent stem cells. Cell Stem Cell 12, 101-113 (2013).

15

Itzhaki, I. et al. Modeling of catecholaminergic polymorphic ventricular tachycardia with human – induced and affected person – particular pluripotent stem cells. Jam. Coll. Cardiol. 60, 990-1000 (2012).

16

Maizels, L. et al. Affected person-specific drug screening utilizing a human-induced pluripotent stem cell mannequin of catecholaminergic kind 2 ventricular polymorphic tachycardia. Circ. Arhythm Electrophysiol 10, e004725 (2017).

17

Bers, D. M. Leakage of calcium within the sarcoplasmic cardiac reticulum: foundation and roles in cardiac dysfunction. Annu. Rev. Physiol. 76, 107-127 (2014).

18

Schreiber, Okay. & Kennedy, B. Okay. When lamins go incorrect: nuclear construction and illness. Cell 152, 1365-1375 (2013).

19

Kervestin, S. & Jacobson, A. NMD: a multifaceted response to the termination of untimely translation. Nat. Rev. Mol. Cell Biol. 13, 700-712 (2012).

20

Seeger, T. et al. A untimely termination codon mutation in MYBPC3 causes hypertrophic cardiomyopathy through continual activation of a nonsense decay. Circulation 139, 799-811 (2019).

21

Luperchio, T.R., Wong, X. & Reddy, Okay. L. Regulation of the genome within the peripheral zone: domains related to lamina in growth and illness. Curr. Opin. Broom. Dev. 25, 50-61 (2014).

22

Guelen, L. et al. Group of the human chromosome area revealed by the mapping of nuclear membrane interactions. Nature 453, 948-951 (2008).

23

Perovanovic, J. et al. Laminopathies disrupt epigenomic growth applications and the destiny of cells. Sci. Trad. Med. eight, 335-58 (2016).

24

Sort, J. & van Steensel, B. Genome – nuclear slide interactions and gene regulation. Curr. Opin. Cell Biol. 22, 320-325 (2010).

25

Chen, X. et al. ATAC-see reveals the genome accessible by imaging and sequencing by transposase. Nat. Strategies 13, 1013-1020 (2016).

26

Gesson, Okay. et al. The kind A lamins bind to each hetero and euchromatin, the latter being regulated by the laminated alpha 2 polypeptide. Genome Res. 26, 462-473 (2016).

27

Rønningen, T. et al. Prepatternation of chromatin domains related to the A / C nuclear layer induced by glcNAcylated H2B histone differentiation. Genome Res. 25, 1825-1835 (2015).

28

Poleshko, A. et al. Genome – nuclear blade interactions regulate the restriction of the lineage of cardiac stem cells. Cell 171, 573-587 (2017).

29

Lachmann, A. et al. Huge extraction of publicly out there RNA-seq knowledge in people and mice. Nat. Frequent. 9, 1366 (2018).

30

Andrae, J., Gallini, R. and Betsholtz, C. Position of Platelet-derived Development Elements in Physiology and Drugs. Genes Dev. 22, 1276-1312 (2008).

31.

Tompkins, J.D. et al. Mapping of pluripotent human differentiation into cardiomyocytes: methylomas, transcriptomes and "recollections" of methylation of exon DNA. EBioMedicine four, 74-85 (2016).

32

Uhlén, M. et al. Tissue map of the human proteome. Science 347, 1260419 (2015).

33

Chintalgattu, V. et al. PDGFR-β signaling of cardiomyocytes is a vital part of the cardiac response of the mouse to stress-induced stress. J. Clin. Make investments. 120, 472-484 (2010).

34

Mattout, A., Cabianca, D.S. & Gasser, S.M. Chromatographic States and Nuclear Group in Improvement – A View of the Nuclear Blade. Genome Biol. 16, 174 (2015).

35

Solovei, I. et al. LBR and laminate A / C sequentially bind peripheral heterochromatin and inversely regulate differentiation. Cell 152, 584-598 (2013).

36

Sharma, A. et al. Excessive throughput screening of cardiotoxicity of tyrosine kinase inhibitors with human-induced pluripotent stem cells. Sci. Trad. Med. 9, eaaf2584 (2017).

37

Lam, C.Okay. et al. New position of HAX-1 within the involvement of warmth shock protein 90 in safety in opposition to ischemic harm Res. 112, 79-89 (2013).

38

Greensmith, evaluation D. J. Ca: an Excel-based program for the evaluation of intracellular calcium transients, together with a number of and simultaneous regression evaluation. Comput. Strategies Biomed applications. 113, 241-250 (2014).

39

Lund, E., Oldenburg, A. R. and Collas, P. Enriched Area Detector: A program to detect massive areas of genomic enrichment which are immune to native variation. Nucleic Acids Res. 42, e92 (2014).

40

Buenrostro, JD, Giresi, P., Zaba, L., Chang, H., Y. and Greenleaf, WJ Transposition of native chromatin for the institution of quick and delicate epigenomic profiles of open chromatin, binding to DNA and nucleosome place. Nat. Strategies 10, 1213-1218 (2013).

41

Langmead, B. and Salzberg, S. L. Speedy alignment with the bow tie 2. Nat. Strategies 9, 357-359 (2012).

42

Ramírez, F., Dündar, F., Diehl, S., Grüning, B. and Manke, T. deepTools: a versatile platform for deep sequencing knowledge mining. Nucleic Acids Res. 42, W187 to W191 (2014).

43

Huber, W. et al. Orchestration of excessive throughput genomic analyzes with Bioconductor. Nat. Strategies 12, 115-121 (2015).

44

Lawrence, M. et al. Laptop software program and annotation of genomic strains. PLOS Comput. Biol. 9, e1003118 (2013).

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