Nature News

Distinct subsets of fibroblasts trigger irritation and lesions in arthritis

1.

Baker, Okay. F. and Isaacs, J. D. New remedies for immune-mediated inflammatory illnesses: what might be discovered from their use in rheumatoid arthritis, spondyloarthritis, systemic lupus erythematosus, psoriasis, Crohn's illness and ulcerative colitis? Ann. Chilly. Dis. 77, 175-187 (2018).

2

Smolen, J.S. & Aletaha, D. Reevaluation of Rheumatoid Arthritis: Methods, Alternatives and Challenges. Nat. Rev Rheumatol. 11, 276-289 (2015).

three

Croft, A. P. et al. Rheumatoid synovial fibroblasts differentiate into distinct subsets within the presence of cytokines and cartilage. Arthritis Res. Ther. 18, 270 (2016).

four

Mizoguchi, F. et al. Fibroblasts related to a functionally distinct illness in rheumatoid arthritis. Nat. Frequent. 9, 789 (2018).

5

Stephenson, W. et al. Unicellular RNA of synovial tissue of rheumatoid arthritis utilizing low-cost microfluidic devices. Nat. Frequent. 9, 791 (2018).

6

Gerlag, D.M., Norris, J.M. and Tak, P.P. In direction of the prevention of rheumatoid arthritis optimistic autoantibodies: from life-style modification to preventive remedy. Rheumatology 55, 607-614 (2016).

7.

Pap, T., Müller-Ladner, U., Homosexual, R.E. & Homosexual, S. Fibroblast biology. Function of synovial fibroblasts within the pathogenesis of rheumatoid arthritis. Arthritis Res. 2, 361-367 (2000).

eight

Ospelt, C. & Homosexual, S. The function of resident synovial cells in harmful arthritis. Finest Pract. Res. Clin. Rheumatol. 22, 239-252 (2008).

9

McGettrick, H.M., Butler, L.M., Buckley, C.D., Rainger, G.E. and Nash, G.B. Tissue stroma as a regulator of leukocyte recruitment in irritation. J. Leukoc. Biol. 91, 385-400 (2012).

ten.

Choi, I. Y. et al. Stromal cell markers are differentially expressed within the synovial tissue of sufferers with early arthritis. PLoS ONE 12, e0182751 (2017).

11

Filer, A. The fibroblast as a therapeutic goal for rheumatoid arthritis. Curr. Opin. Pharmacol. 13, 413-419 (2013).

12

Kollias, G. et al. Animal fashions of arthritis: revolutionary instruments of prevention and remedy. Ann. Chilly. Dis. 70, 1357-1362 (2011).

13

Roberts, E.W. et al. The depletion of stromal cells expressing α-protein activation of fibroblasts from skeletal muscle and bone marrow ends in cachexia and anemia. J. Exp. Med. 210, 1137-1151 (2013).

14

Avenue, Okay. et al. Slingshot: Cell line and pseudotime inference for single-cell transcriptomics. BMC Genomics 19, 477 (2018).

15

Zhang, F. et al. Definition of inflammatory cell states within the synovial tissues of rheumatoid arthritis by integration of unicellular transcriptomic and mass cytometry. Preprint at https://www.biorxiv.org/content material/10.1101/351130v1 (2018).

16

Butler, A., Hoffman, P., Smibert, P., Papalexi, E. and Satija, R. Integration of unicellular transcriptomic information beneath totally different circumstances, applied sciences and species. Nat. Biotechnol. 36, 411-420 (2018).

17

Filer, A. et al. Identification of a transient fibroblast operate in very early rheumatoid arthritis. Ann. Chilly. Dis. 76, 2105-2112 (2017).

18

Donlin, L. T. et al. Strategies of high-density evaluation of dissociated cells of the cyropreserved synovial tissue. Arthritis. Res. Ther. 20, 139 (2018).

19

Krenn, V. et al. Synovitis rating: Discrimination between low grade and excessive grade power synovitis. Histopathology 49, 358-364 (2006).

20

Sinha, R. et al. Index switching causes "sign propagation" amongst multiplexed samples in Illumina HiSeq 4000 DNA sequencing. Preprint on https://doi.org/10.1101/125724 (2017).

21

Tirosh, I. et al. Unicellular RNA-seq helps a growth hierarchy within the human oligodendroglioma. Nature 539, 309-313 (2016).

22

Ashburner, M. et al. Gene ontology: a device for unifying biology. Nat. Broom. 25, 25-29 (2000).

23

Dobin, A. et al. STAR: ultra-fast common aligner of ARN-seq. Bioinformatics 29, 15-21 (2013).

24

Love, M. I., Huber, W. and Anders, S. Reasonable estimate of fold change and dispersion for seq-RNA information with DESeq2. Genome Biol. 15, 550 (2014).

25

Luo, W., Friedman, M.S., Shedden, Okay., Hankenson, Okay.D. and Woolf, P. J. GAGE: Common enrichment of gene units for pathway evaluation. BMC Bioinformatics 10, 161 (2009).

26

Ross, E.A., et al. Therapy of inflammatory arthritis by concentrating on tristetraproline, a key regulator of pro-inflammatory gene expression. Ann. Chilly. Dis. 76, 612 to 619 (2017).

27

Wehmeyer, C. et al. The inhibition of sclerostin promotes inflammatory joint destruction associated to TNF. Sci. Trad. Med. eight, 330ra35 (2016).

Leave a Reply

Your email address will not be published. Required fields are marked *