Nature News

Distinct subsets of fibroblasts trigger irritation and lesions in arthritis


Baker, Okay. F. and Isaacs, J. D. New remedies for immune-mediated inflammatory illnesses: what might be discovered from their use in rheumatoid arthritis, spondyloarthritis, systemic lupus erythematosus, psoriasis, Crohn's illness and ulcerative colitis? Ann. Chilly. Dis. 77, 175-187 (2018).


Smolen, J.S. & Aletaha, D. Reevaluation of Rheumatoid Arthritis: Methods, Alternatives and Challenges. Nat. Rev Rheumatol. 11, 276-289 (2015).


Croft, A. P. et al. Rheumatoid synovial fibroblasts differentiate into distinct subsets within the presence of cytokines and cartilage. Arthritis Res. Ther. 18, 270 (2016).


Mizoguchi, F. et al. Fibroblasts related to a functionally distinct illness in rheumatoid arthritis. Nat. Frequent. 9, 789 (2018).


Stephenson, W. et al. Unicellular RNA of synovial tissue of rheumatoid arthritis utilizing low-cost microfluidic devices. Nat. Frequent. 9, 791 (2018).


Gerlag, D.M., Norris, J.M. and Tak, P.P. In direction of the prevention of rheumatoid arthritis optimistic autoantibodies: from life-style modification to preventive remedy. Rheumatology 55, 607-614 (2016).


Pap, T., Müller-Ladner, U., Homosexual, R.E. & Homosexual, S. Fibroblast biology. Function of synovial fibroblasts within the pathogenesis of rheumatoid arthritis. Arthritis Res. 2, 361-367 (2000).


Ospelt, C. & Homosexual, S. The function of resident synovial cells in harmful arthritis. Finest Pract. Res. Clin. Rheumatol. 22, 239-252 (2008).


McGettrick, H.M., Butler, L.M., Buckley, C.D., Rainger, G.E. and Nash, G.B. Tissue stroma as a regulator of leukocyte recruitment in irritation. J. Leukoc. Biol. 91, 385-400 (2012).


Choi, I. Y. et al. Stromal cell markers are differentially expressed within the synovial tis